The following guide highlights the most effective chemical sprays and barriers to target spiders, including common house spiders, black widows, and other web wanderers. Each product page summarizes performance, application scope, and key features to help you choose the right solution for indoor or outdoor use.
Summary of selected products:
| Product | Brand | Key Benefit |
|---|---|---|
| Hot Shot Spider & Scorpion Killer (Aerosol) | HOT SHOT | Fast knockdown; long-lasting residual up to 4 months |
| TERRO T2302 Spider, Ant, Roach Killer | Terro | Kills spiders on contact; broad insect coverage |
| STEM Kills Ants, Roaches And Spiders | STEM | Plant-based, pet-safe formulation |
| Wet & Forget Miss Muffet’s Revenge | Wet & Forget | Indoor/outdoor barrier with long-lasting protection |
| Ortho Home Defense Max Indoor Insect Barrier | Ortho | Monolithic barrier around the home for 365 days |
Hot Shot Spider & Scorpion Killer

HOT SHOT Spider & Scorpion Killer delivers a fast-acting formula designed to kill spiders, scorpions, and other listed insects within seconds. The product offers residual control for up to four months, continuing to kill ants (excluding harvester, pharaoh, and fire ants), cockroaches, and crickets. It also targets black widow spiders as they hatch, providing a broader protective window. This aerosol is suitable for indoor and outdoor use in areas where spiders are commonly found, such as basements, garages, and around entry points.
TERRO T2302 Spider, Ant, Roach Killer

Terro’s T2302 spray provides on-contact kill for a range of pests, including spiders (Black Widow and Brown Recluse among others), ants, cockroaches, crickets, and scorpions. This 2-pack offers extended coverage for larger spaces such as garages or multi-room homes. The product emphasizes rapid action with immediate effect on contact, helping to quickly reduce visible spider populations and prevent re-infestation when used as part of a broad pest management plan.
STEM Kills Ants, Roaches And Spiders

STEM offers a plant-based active ingredient bug killer designed for indoor and outdoor use. This botanical insecticide claims to kill ants, roaches, and spiders while being safer around people and pets when used as directed. Entomologist-tested, it features a fresh scent with no added dye or harsh chemical odors, appealing to households seeking a more natural pest control option without sacrificing effectiveness. It is best used as part of an integrated approach that combines sanitation and exclusion with protective treatments.
Wet & Forget Miss Muffet’s Revenge

Miss Muffet’s Revenge from Wet & Forget is designed to kill spiders and create a barrier that keeps them away for up to 12 months with a single application. This ready-to-use formula includes an attached sprayer with a spray range of up to 10 feet, enabling easier reach for ceilings, corners, and other high-traffic spider zones. It emphasizes long-lasting residual control and is formulated for both indoor and outdoor use to protect entryways, windows, and foundational areas where spiders frequently travel.
Ortho Home Defense Max Indoor Insect Barrier

Ortho Home Defense Max Indoor Insect Barrier provides a durable indoor spray option that creates a protective barrier against ants, roaches, spiders, fleas, and ticks for up to a year on nonporous surfaces. The application is suited for kitchens, bathrooms, basements, doors, and windows, with a broader outdoor component to guard foundations. The Comfort Wand applicator allows easier reach into corners and along baseboards, supporting a more thorough treatment of spider-prone areas.
Spectracide Bug Stop Home Barrier

Spectrum’s Bug Stop Home Barrier offers indoor and outdoor control with on-contact action against ants, roaches, and spiders. This 1.33-gallon container is positioned as a ready-to-apply solution that can be refilled with compatible AccuShot sprayers. It emphasizes a stable barrier effect across nonporous surfaces, helping to prevent reinfestation in adjacent rooms and exterior spaces such as porches and patios. It is commonly used by homeowners seeking a large-volume option for ongoing protection.
Revenge Spider & Ground Bee Killer

Revenge Spider & Ground Bee Killer is a topical dust treatment designed for indoor and outdoor use, repelling and killing spiders and ground bees. It is suitable for tight spaces such as cracks, crevices, and wall voids when applied as directed. The product is versatile for both interior corners and exterior eaves or porches, contributing to a multi-faceted approach to spider control and preventive barrier formation in high-traffic areas.
Buying Guide: Key Purchase Considerations
- Target pests: Some formulas are optimized for a broad range of insects, while others emphasize spider-specific action or inclusion of scorpions. Choose based on the pest profile in your space.
- Application scope: Indoor-only, outdoor-only, or indoor-outdoor products will influence where you deploy them. Consider entry points, basements, garages, and exterior foundations.
- Residual protection: Look for products that offer longer residual control if you want less frequent applications, but balance with a safer formulation for household members and pets.
- Safety and scent: Plant-based or low-odor formulations may be preferable for homes with children or pets. Always follow label directions for usage and storage.
- Surface compatibility: Check whether the product is safe on porous or nonporous surfaces, and whether it is suitable for kitchens, bathrooms, or living areas.
- Application equipment: Sprayers, wands, or ready-to-use aerosols can affect ease of use. Some products include attached sprayers for reach in hard-to-clean areas.
- Integrated approach: Combining chemical treatments with sanitation, sealing gaps, and reducing attractants yields better long-term spider control than chemicals alone.
When selecting a chemical solution to kill spiders, evaluate the pest presence in your space, the level of exposure risk, and your preferred application method. A product with broad insect coverage and a strong residual barrier may be advantageous in mixed-pest environments, while a plant-based option could suit households prioritizing natural formulations. Use as part of a comprehensive spider management plan for best results.